208293

Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01

The Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 controls the biological activity of Calcium-activated Chloride Channel.

• 別名: Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I, ANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, TMEM16 Blocker I, ANO Blocker I, Anoctamin Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
• 実験式（ヒル表記法）: C₁₈H₂₁NO₄S
• CAS番号: 407587-33-1
• 分子量: 347.43
• MDL番号: MFCD02919058
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 50 mg/mL, pale yellow
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1

詳細

詳細

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC₅₀ = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC₅₀ = 2.1 µM).

An aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC₅₀ = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC₅₀ = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Fuente, R., et al. 2011, Mol Pharmacol.73, 758.
Namkung, W., et al. 2011, J Biol Chem.286, 2365.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable