191501

1-Azakenpaullone

InSolution, ≥94%, ATP-competitive inhibitor of GSK-3Beta

• 別名: InSolution 1-Azakenpaullone
• 実験式（ヒル表記法）: C₁₅H₁₀BrN₃O
• CAS番号: 676596-65-9
• 分子量: 328.16
• MDL番号: MFCD09037522
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥94% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChI Key: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

詳細

詳細

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
GSK-3β

Reversible: yes

Target IC₅₀: 18 nM for GSK-3&beta

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

再構成

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

その他情報

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 引火点(℃): 87 °C - closed cup - (refers to pure substance)