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アプリケーション
Suitable for use as an inhibitor of serine/threonine-specific protein phosphatases.
品質
Routinely evaluated as an inhibitor in a kinase assay.
保管および安定性
Lyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
保管分類コード
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
Redpath, N T and Proud, C G
The Biochemical Journal, 262, 69-75 (1989)
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Wheat, W H, et al.
Molecular and cellular biology, 14, 5881-5890 (1994)
F M Amara et al.
The Journal of biological chemistry, 271(33), 20126-20131 (1996-08-16)
Mammalian ribonucleotide reductase is a highly regulated activity essential for DNA synthesis and repair. The 3'-untranslated region (3'-UTR) of mammalian ribonucleotide reductase R2 mRNA has been implicated in the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate-mediated stabilization of mouse BALB/c 3T3 R2 message. We
Okadaic acid. Protein phosphatase inhibition and muscle contractile effects.
Takai, A
Journal of Muscle Research and Cell Motility, 9, 563-565 (1988)
E G Mimnaugh et al.
The Journal of biological chemistry, 270(48), 28654-28659 (1995-12-01)
The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs its cellular trafficking and negatively regulates its kinase activity. Here we report that the serine/threonine phosphatase inhibitor, okadaic acid, destabilized the
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