178494

Apoptosis Inhibitor II, NS3694

The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Apoptosis Inhibitor II, NS3694, NS3694
• 実験式（ヒル表記法）: C₁₅H₁₀ClF₃N₂O₃
• CAS番号: 426834-38-0
• 分子量: 358.70
• MDL番号: MFCD00249000
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 10 mg/mL; ethanol: slightly soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)
• InChI Key: GNCZTZCPXFDPLI-UHFFFAOYSA-N

詳細

詳細

A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.

A cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Apoptosome complex formation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells

警告

Toxicity: Standard Handling (A)

その他情報

Lademann, U., et al. 2003. Mol. Cell. Biol.23, 7829.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable