172060

Andrographolide

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

• 別名: Andrographolide, Andro
• 実験式（ヒル表記法）: C₂₀H₃₀O₅
• CAS番号: 5508-58-7
• 分子量: 350.45
• MDL番号: MFCD07778082
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• 詳細: Merck USA index - 14, 633
• アッセイ: ≥95% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: chloroform: methanol (1:1): 10 mg/mL; DMSO: 15 mg/mL (Use only fresh DMSO.)
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: O1CC(\C(=C/C[C@H]2[C@]3(C(C(C(CC3)O)(CO)C)CCC2=C)C)\C1=O)O
• InChI: 1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15?,16?,17?,19+,20?/m1/s1
• InChI Key: BOJKULTULYSRAS-ZJFCSBQFSA-N

詳細

詳細

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.

An irreversible blocker of NF-κB and AP-1 (IC₅₀ ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
NF-κB and AP-1 activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: ≤ 15 µM against NF-κB and AP-1 activation

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Xia, Y.F., et al. 2004. J. Immunol.173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337.
Yu, B.C., et al. 2003. Planta Med.69, 1075.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable