149101-M

1-Aminocyclopropanecarboxylic acid

≥98% (TLC), crystalline solid, NMDA agonist, Calbiochem

• 別名: 1-Aminocyclopropane-1-carboxylic Acid, ACPC
• 実験式（ヒル表記法）: C₄H₇NO₂
• CAS番号: 22059-21-8
• 分子量: 101.10
• MDL番号: MFCD00009944
• UNSPSCコード: 12352106
• NACRES: NA.77

特性

• product name: 1-Aminocyclopropane-1-carboxylic Acid, An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: water: 40 mg/mL
• 保管温度: 10-30°C
• InChI: 1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
• InChI Key: PAJPWUMXBYXFCZ-UHFFFAOYSA-N

詳細

詳細

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

生物化学的／生理学的作用

Primary Target
Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

警告

Toxicity: Irritant (B)

調製ノート

May require heating and sonication to achieve complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

その他情報

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.
Zapata, A., et al. 1996. NeuroReport7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable