14-902-M

AMPK (α2, β1, γ1) Protein, active, 10 µg

Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in E. coli
• 製品種目: Upstate^®
• 比活性: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• 分子量: M_w 30 kDa (AMPKß1); M_w 38 kDa (AMPKγ1); M_w 63 kDa (AMPKα2)
• 精製方法: (Ni²⁺/NTA-agarose)
• 交差性: human
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• アクセッション番号: (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ); NM_006252
• NCBIアクセッション番号: NM_002733; NM_006252; NM_006253
• UniProtアクセッション番号: P54619; P54646; P54646, Q9Y478, P54619; Q9Y478
• 関連疾患: diabetes; obesity; metabolic disorders
• 遺伝子情報: human ... PRKAA2(5563) , PRKAB1(5563)

詳細

詳細

Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.

アプリケーション

Research Category
代謝

アポトーシス及び癌

Research Sub Category
糖尿病

肥満

代謝障害

生物化学的／生理学的作用

Protein Target: AMPK (α2, β1, γ1)

Target Sub-Family: CAMK

包装

Also available in 10 μg size and in bulk

Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

品質

Routinely evaluated by phosphorylation of substrate peptide

ターゲットの説明

AMPK (α2, β1, γ1)

物理的形状

Cobalt-agarose

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(℃): Not applicable