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由来生物
human
品質水準
リコンビナント
expressed in Sf9 cells
分子量
Mw 44 kDa (cdk9)
Mw 80.79 kDa (cyclinT1)
メーカー／製品名
Upstate®
テクニック
activity assay: suitable (kinase)
NCBIアクセッション番号
UniProtアクセッション番号
遺伝子情報
human ... CDK9(1025)
詳細
C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1
Product Source: expressed by baculovirus in Sf21 insect cells
アプリケーション
Research Category
炎症及び免疫
炎症及び免疫
生物化学的／生理学的作用
Protein Target: CDK9/cyclin T1
Target Sub-Family: CMGC
品質
routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401)
物理的形状
Ni2+/NTA-agarose
保管および安定性
stable for 6 months at -70°C from date of shipment
その他情報
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
Sano, Motoaki and Schneider, Michael D
Cell Cycle, 2, 99-104 (2003)
Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Garriga, Judit and Gra?a, Xavier
Gene, 337, 15-23 (2004)
Li-Ying Liou et al.
The international journal of biochemistry & cell biology, 36(9), 1767-1775 (2004-06-09)
The macrophage is an important cell type in the pathophysiology of human immunodeficiency virus type 1 (HIV-1) infection. Macrophages both support viral replication and are capable of attracting and activating lymphocytes, thus rendering CD4+ T lymphocytes highly permissive for infection.
Tinggui Yin et al.
Molecular cancer therapeutics, 13(6), 1442-1456 (2014-04-02)
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CTD. Given the reported dysregulation of
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