1.37165

スペルミジン

EMPROVE^® EXPERT

• 別名: 1,8-ジアミノ-4-アザオクタン, N-(3-アミノプロピル)-1,4-ジアミノブタン
• 化学式: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS番号: 124-20-9
• 分子量: 145.25
• Beilstein: 1698591
• MDL番号: MFCD00008229
• UNSPSCコード: 12352103
• EC Index Number: 204-689-0

特性

• 由来生物: synthetic
• 品質水準: 500
• グレード: GMO free; GMP
• 詳細: Aflatoxin-free; Melamin-free; DNase-free; RNase-free
• 製品種目: EMPROVE^® EXPERT
• 不純物: low in endotoxins
• 屈折率: n20/D 1.479 (lit.)
• 粒径: (liquid or solidified mass)
• 密度: 0.925 g/mL at 25 °C (lit.)
• アプリケーション: pharma/biopharma processes; pharmaceutical
• 保管温度: 15-25°C
• SMILES記法: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChI Key: ATHGHQPFGPMSJY-UHFFFAOYSA-N

詳細

詳細

Finding the right critical raw material that matches your quality expectation can be challenging. Especially if you are advancing through clinical phases, changing regulatory requirements can raise several questions.

As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Spermidine has several applications beyond its chemical behavior as a base. The amino groups can interact with the phosphate groups of DNA and RNA and stabilize them. In addition, spermidine has a positive impact on transcription by RNA polymerases and can be found in several buffers. Within RNA bioprocessing, spermidine can be used for purification to bind and precipitate DNA. It may also be considered as adjuvant for mRNA vaccines.

The EMPROVE^® Expert quality grade provided with this product is tested for microbial and endotoxin levels and is RNase- and DNase-free. Stability studies according to ICH Q7 are running and stability conclusions will be available via EMPROVE^® Suite.

生物化学的／生理学的作用

神経型一酸化窒素合成酵素（nNOS）を阻害します。DNAに結合し沈殿させ、DNA結合タンパク質の精製に使用できます。T₄ポリヌクレオチドキナーゼ活性を刺激します。

神経型一酸化窒素合成酵素（nNOS）を阻害します。DNAに結合し沈殿させます。T₄ポリヌクレオチドキナーゼ活性を刺激します。

注意

滅菌が必要な場合は、オ-トクレ-ブではなく、濾過滅菌を行ってください。スペルミジンは経時的に脱アミノ化するので、溶液は凍結保存してください。溶液は用時調製してください。

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H314
• 注意書き: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• 危険有害性の分類: Eye Dam. 1 - Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): 233.6 °F - closed cup
• 引火点(℃): 112 °C - closed cup