1.37159

DL-ジチオトレイトール

EMPROVE^® ESSENTIAL

• 別名: threo-1,4-ジメルカプト-2,3-ブタンジオール, Cleland試薬, DTT
• 化学式: HSCH₂CH(OH)CH(OH)CH₂SH
• CAS番号: 3483-12-3
• 分子量: 154.25
• Beilstein: 1719757
• MDL番号: MFCD00004877
• UNSPSCコード: 12352200
• EC Index Number: 222-468-7

特性

• 由来生物: synthetic
• 品質水準: 500
• 製品種目: EMPROVE^® ESSENTIAL
• mp: 41-44 °C (lit.)
• アプリケーション: pharma/biopharma processes
• 保管温度: −20°C (−15°C to −25°C)
• SMILES記法: O[C@H](CS)[C@H](O)CS
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
• InChI Key: VHJLVAABSRFDPM-QWWZWVQMSA-N

詳細

詳細

Our SAFC Pharma^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.
M-Clarity Program
As part of our Emprove^® Program, our raw materials are offered with Emprove^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

アプリケーション

SH基を還元状態に保つ試薬です。ジスルフィドを定量的 に還元します。SDS-PAGEのサンプルバッファーに加えることで、タンパク質のジスルフィド結合の還元に効果を発揮します。また、架橋剤であるN,N′-ビス(アクリロイル)シスタミンのジスルフィド結合を還元してポリアクリルアミドゲルのマトリックスを切り離す目的でも用いられます。2-メルカプトエタノールと比較して、刺激性および毒性が抑えられています。通常、2-メルカプトエタノールの使用濃度(5% v/v、700 mM)の7分の1濃度(100 mM)で効果を発揮します。

DTT is an excellent reagent chemical used to reduce disulfide bonds commonly found in bioprocessing. DTT is used in buffer formulations to maintain and stabilize free -SH in applications such as protein based biotherapeutics and enzyme stability.

包装

1.37159.0010 / 10 g / Amber glass bottle
1.37159.0100 / 100 g / Amber glass bottle
1.37159.1000 / 1 kg / LDPE bag with outer HDPE drum
1.37159.9010 / 10 kg / LDPE bag with outer HDPE drum

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC Pharma is a registered trademark of Sigma-Aldrich Co. LLC

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302 - H315 - H318
• 注意書き: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable