124013

Akt Inhibitor VI, Akt-in

The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Akt Inhibitor VI, Akt-in, TCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
• 実験式（ヒル表記法）: C₈₈H₁₂₃N₂₃O₂₃
• 分子量: 1871.06
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.

A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL_10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.

生物化学的／生理学的作用

Cell permeable: no

Kd ~18 µM in binding to Akt-PH domain

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

シーケンス

H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

物理的形状

Supplied as an acetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable