1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• 別名: Pepsin
• CAS番号: 9001-75-6
• 分子量: 35000
• MDL番号: MFCD00081840
• UNSPSCコード: 12352204
• EC Index Number: 232-629-3
• NACRES: NA.21

特性

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• 溶解性: 10 g/L
• かさ密度: 380‑420 kg/m³
• 保管温度: 2-30°C

詳細

アプリケーション

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

生物化学的／生理学的作用

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

アナリシスノート

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

安全性情報

• ピクトグラム: GHS07,GHS08
• シグナルワード: Danger
• 危険有害性情報: H315 - H319 - H334 - H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable