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詳細
Rho proteins belong to the Ras super family of low molecular weight GTPases, which includes RAS, RHO, RAB, RAN, RAD and ARF. These small GTP binding proteins function as molecular switches that regulate a multitude of biological processes including cell proliferation, apoptosis, differentiation, cytoskeletal reorganization, and membrane trafficking.
特異性
Recognizes Rho (-A, -B, -C), Mr 22 kDa.
免疫原
Recombinant human RhoA containing amino acids 1-155. Clone 55.
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
細胞骨格シグナル伝達
細胞骨格シグナル伝達
Detect Rho (-A, -B, -C) using this Anti-Rho (-A Antibody, -B, -C), clone 55 validated for use in IC & WB.
Immunocytochemistry:
This antibody has been reported by an independent laboratory to detect Rho in cells via immunofluorescence.
This antibody has been reported by an independent laboratory to detect Rho in cells via immunofluorescence.
品質
Routinely evaluated by western blot on RIPA lysates from Jurkat or HL-60 cells.
Western Blot Analysis:
0.5-2 µg/mL of this lot detected Rho in RIPA lysates from HL-60 cells. A previous lot detected Rho in RIPA lysates from Jurkat cells.
Western Blot Analysis:
0.5-2 µg/mL of this lot detected Rho in RIPA lysates from HL-60 cells. A previous lot detected Rho in RIPA lysates from Jurkat cells.
ターゲットの説明
22 kDa
物理的形状
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1 in buffer containing BSA containing 0.09% sodium azide and 50% glycerol.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations:
Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20ºC may cause glycerol-containing solutions to become frozen during storage.
Handling Recommendations:
Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20ºC may cause glycerol-containing solutions to become frozen during storage.
アナリシスノート
Control
HL-60 cell lysate.
HL-60 cell lysate.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
05-778:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway.
Guosong Qiu,John S Hill
Journal of Cardiovascular Pharmacology null
Marina Sycheva et al.
Brain sciences, 9(8) (2019-08-23)
We have previously shown that the expression of pro-nerve growth factor (proNGF) was significantly increased, nerve growth factor (NGF) level was decreased, and the expression of p75NTR was enhanced in Alzheimer's disease (AD) hippocampal samples. NGF regulates cell survival and
Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.
El-Remessy, Azza B, et al.
Experimental Diabetes Research, 2010, 247861-247861 (2010)
Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes.
Hauck, L; Harms, C; Grothe, D; An, J; Gertz, K; Kronenberg, G; Dietz, R; Endres, M; von Harsdorf, R
Circulation Research null
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy.
Abdelsaid, Mohammed A, et al.
Journal of Pharmacology and Experimental Therapeutics, 332, 125-134 (2010)
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