おすすめの製品
由来生物
mouse
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
A16/17, monoclonal
化学種の反応性
mouse, human, rat
メーカー／製品名
Upstate®
テクニック
immunoprecipitation (IP): suitable
western blot: suitable
アイソタイプ
IgG1κ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
mouse ... Grk4(14772)
特異性
GRK 4, GRK 5 and GRK 6
免疫原
GST fusion protein corresponding to residues 463-590 of bovine GRK 5
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
GPCR、cAMP/cGMP及びカルシウムシグナル伝達
GPCR、cAMP/cGMP及びカルシウムシグナル伝達
Anti-GRK 4-6 Antibody, clone A16/17 detects level of GRK 4-6 & has been published & validated for use in IP & WB.
品質
routinely evaluated by immunoblot on murine 3T3/A31 RIPA lysate or human K562 cells
ターゲットの説明
65-70kDa
物理的形状
Ammonium Sulfate Precipitation
0.1M Tris-glycine, pH 7.4, 0.15 NaCl with 0.05% sodium azide
Format: Purified
保管および安定性
2 years at -20°C
アナリシスノート
Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Y Nagayama et al.
The Journal of biological chemistry, 271(17), 10143-10148 (1996-04-26)
Homologous desensitization of G protein-coupled receptors involves agonist-dependent phosphorylation of receptors by G protein-coupled receptor kinases (GRKs). To identify GRK(s) that play a role in homologous desensitization of the thyrotropin (TSH) receptor, thyroid cDNA was amplified by polymerase chain reaction
E R Bychkov et al.
Neurobiology of aging, 29(3), 379-396 (2006-11-28)
Arrestins and G proteins-coupled receptor kinases (GRKs) regulate signaling and trafficking of G protein-coupled receptors. We investigated changes in the expression of arrestins and GRKs in the striatum of patients with Parkinson's disease without (PD) or with dementia (PDD) at
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
Pitcher, J A, et al.
The Journal of Biological Chemistry, 271, 24907-24913 (1996)
Sudipto Das et al.
Pflugers Archiv : European journal of physiology, 464(1), 101-109 (2012-04-25)
Mitochondrial structure and function are central to cell physiology and are mutually interdependent. Mitochondria represent a primary target of the alcohol-induced tissue injury, particularly in the liver, where the metabolic effects of ethanol are predominant. However, the effect of ethanol
Weiwei Wu et al.
PloS one, 15(4), e0232019-e0232019 (2020-04-29)
Parkinson's disease (PD) is a common neurodegenerative disorder which is mostly sporadic but familial-linked PD (FPD) cases have also been found. The first reported gene mutation that linked to PD is α-synuclein (α-syn). Studies have shown that mutations, increased expression
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