05-1117

Anti-VEGF Antibody, clone VG1

ascites fluid, clone VG1, from mouse

• 別名: Vascular permeability factor, vascular endothelial growth factor, vascular endothelial growth factor A, vascular endothelial growth factor isoform VEGF165
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: ascites fluid
• クローン: VG1, monoclonal
• 化学種の反応性: mouse, human, rat
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_033531.3
• UniProtアクセッション番号: P15692
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines.

特異性

Detects the 121, 165, and 189 amino acid isoforms of VEGF.

免疫原

Recombinant human VEGF 189aa isoform

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
成長因子及び受容体

Detect VEGF using this Anti-VEGF Antibody, clone VG1 validated for use in WB.

品質

Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate.

ターゲットの説明

Approx. 12-28 kDa

関連事項

Replaces: MAB3734

物理的形状

Unpurified

Unpurified mouse monoclonal IgG1κ in ascites fluid containing no preservatives.

保管および安定性

Stable for 12 months at -20°C from date of receipt.
Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

アナリシスノート

Control
NIH/3T3 cell lysate

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable