04-823
Anti-phospho-GluR1 (Ser831) Antibody, clone N453, rabbit monoclonal
culture supernatant, clone N453, Upstate®
別名:
AMPA 1, AMPA-selective glutamate receptor 1, Glutamate receptor ionotropic, AMPA 1, glutamate receptor, ionotropic, AMPA 1
ログイン組織・契約価格を表示する
すべての画像(1)
About This Item
UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
おすすめの製品
由来生物
rabbit
品質水準
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
N453, monoclonal
化学種の反応性
mouse, chicken, human, rat
メーカー／製品名
Upstate®
テクニック
western blot: suitable
アイソタイプ
IgG
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
ターゲットの翻訳後修飾
phosphorylation (pSer831)
遺伝子情報
human ... GRIA1(2890)
詳細
L glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors that have been divided into 3 groups. Group I includes GRM1 and these receptors have been shown to activate phospholipase C. GRM1 expression has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries.
特異性
Predicted cross-reactivity with human, mouse and chicken
Recognizes GluR1 phosphorylated on Serine 831.
免疫原
KLH-conjugated, synthetic peptide containing the sequence ...QQ[pS]IN… in which pS corresponds to phospho-serine at position 831 of the GluR1 mature chain. Sequence is identical in human, rat, mouse and chicken.
アプリケーション
Research Category
ニューロサイエンス
ニューロサイエンス
Research Sub Category
神経伝達物質及び受容体
神経伝達物質及び受容体
Western Blot Analysis:
A 1:1,000-1:4,000 dilution of this lot detected phosphorylated GluR1 from a rat brain microsomal preparation (Catalog # 12-144).
A 1:1,000-1:4,000 dilution of this lot detected phosphorylated GluR1 from a rat brain microsomal preparation (Catalog # 12-144).
Anti-phospho-GluR1 (Ser831) Antibody, clone N453 detects level of phospho-GluR1 (Ser831) & has been published & validated for use in WB.
品質
routinely evaluated by western blot
ターゲットの説明
106 kDa
関連事項
Replaces: 05-823
物理的形状
Cultured supernantant in 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap.
For maximum recovery of product, centrifuge the vial prior to removing the cap.
アナリシスノート
Control
Rat brain
Rat brain
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
04-823:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
A Barria et al.
The Journal of biological chemistry, 272(52), 32727-32730 (1998-01-31)
Ca2+/CaM-dependent protein kinase II (CaM-KII) can phosphorylate and potentiate responses of alpha-amino3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptors in a number of systems, and recent studies implicate this mechanism in long term potentiation, a cellular model of learning and memory. In this study we
K W Roche et al.
Neuron, 16(6), 1179-1188 (1996-06-01)
We have characterized the phosphorylation of the glutamate receptor subunit GluR1, using biochemical and electrophysiological techniques. GluR1 is phosphorylated on multiple sites that are all located on the C-terminus of the protein. Cyclic AMP-dependent protein kinase specifically phosphorylates SER-845 of
The striatal mosaic in primates: striosomes and matrix are differentially enriched in ionotropic glutamate receptor subunits.
Martin, L J, et al.
The Journal of Neuroscience, 13, 782-792 (1993)
Juhwan Kim et al.
Molecules and cells, 41(5), 454-464 (2018-05-15)
Crosstalk between G-protein signaling and glutamatergic transmission within the brain reward circuits is critical for long-term emotional effects (depression and anxiety), cravings, and negative withdrawal symptoms associated with opioid addiction. A previous study showed that Regulator of G-protein signaling 4
Héctor De Jesús-Cortés et al.
Neuroscience, 329, 66-73 (2016-05-08)
Eating disorders (EDs), including anorexia nervosa, bulimia nervosa and binge-ED, are mental illnesses characterized by high morbidity and mortality. While several studies have identified neural deficits in patients with EDs, the cellular and molecular basis of the underlying dysfunction has
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）