Z-021

Ziprasidone hydrochloride solution

1 mg/mL ((as free base), Methanol:DMSO (80:20) (m/m)), certified reference material, ampule of 1 mL, Cerilliant^®

• 実験式（ヒル表記法）: C₂₁H₂₁ClN₄OS · HCl
• CAS番号: 122883-93-6
• 分子量: 449.40
• MDL番号: MFCD06795476
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 1 mg/mL ((as free base), Methanol:DMSO (80:20) (m/m))
• フォーマット: single component solution
• 保管温度: -10 to -25°C
• InChI: 1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H;1H2
• InChI Key: ZCBZSCBNOOIHFP-UHFFFAOYSA-N

詳細

詳細

A Certified Spiking Solution^® applicable to use in forensic drug analysis or calibrator preparation by LC/MS or GC/MS. Ziprasidone is sold under the trade names Geodon and Zeldox for treatment of schizophrenia and bipolar disorder. Recent studies have suggested that Ziprasidone may increase the risk of Type II diabetes and hyperglycemia.

アプリケーション

• Enhanced Drug Delivery Systems: A study detailed the development of sustained-release ziprasiDonemicroparticles using Soluplus and ethyl cellulose. This formulation aims to eliminate the food effect and enhance bioavailability, marking a significant advancement in pharmaceutical formulations for schizophrenia treatment (Liu W et al., 2019).


• Targeted CNS Delivery:The study evaluated the brain-targeting and antipsychotic activities of nasally administered ziprasiDonethrough lipid-polymer hybrid nanocarriers. This novel delivery method could revolutionize treatment approaches in psychiatric medicine by enhancing drug efficacy and patient compliance in schizophrenia management (Abo El-Enin HA et al., 2023).


• Real-world Effectiveness in Bipolar Disorder:The study conducted a register-based national cohort study on the real-world effectiveness of pharmacological treatments for bipolar disorder, including ziprasidone. This research provides valuable insights into the therapeutic impacts and side effect profiles of ziprasiDonein a large patient population (Lahteenvuo M et al., 2023).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 71.6 °F
• 引火点(℃): 22 °C