N-920

Norbuprenorphine-D₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 別名: Norbuprenorphine-d₃
• 実験式（ヒル表記法）: C₂₅H₃₂D₃NO₄
• CAS番号: 350482-19-8
• 分子量: 416.57
• EC Number: 200-659-6
• MDL番号: MFCD01861544
• UNSPSCコード: 41116107
• PubChem Substance ID: 329818614
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• 形状: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland)
• 濃度: 100 μg/mL in methanol
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: forensics and toxicology
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: [2H]C([2H])([2H])O[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4)c56
• InChI: 1S/C25H35NO4/c1-21(2,3)22(4,28)16-13-23-8-9-25(16,29-5)20-24(23)10-11-26-17(23)12-14-6-7-15(27)19(30-20)18(14)24/h6-7,16-17,20,26-28H,8-13H2,1-5H3/t16-,17-,20-,22+,23-,24+,25-/m1/s1/i5D3
• InChI Key: YOYLLRBMGQRFTN-QLWKBOQPSA-N

詳細

詳細

Norbuprenorphine is the primary active metabolite of the opiate buprenorphine in urine. This internal standard is suitable for quantitation of norbuprenorphine levels or isotope dilution methods by GC/MS or LC/MS for pain prescription monitoring, clinical toxicology, urine drug testing or forensic analysis. Buprenorphine, sold under trade names such as Buprenex^®, Subutex^® and Suboxone^®, is an opiate drug used to treat opioid addiction and moderate to acute pain.

アプリケーション

• Improving GC-MS Analysis of Norbuprenorphine: A study by Gervais JR and Hobbs GA discusses the use of an acetyl derivative to enhance the GC-MS analysis of Norbuprenorphine in urine, particularly in the presence of high concentrations of Buprenorphine, highlighting its significance as an analytical standard in forensic and clinical toxicology (Gervais and Hobbs, 2016).
• Quantification of Acetaminophen Protein Adducts: Cook SF et al. developed a method for the quantification of a biomarker for acetaminophen protein adducts in human serum using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. This study demonstrates the application of advanced analytical techniques in toxicology and pharmacokinetics, where Norbuprenorphine-D3 serves as a reliable internal standard (Cook et al., 2015).

法的情報

Buprenex is a registered trademark of Reckitt & Colman (Overseas) Ltd

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Suboxone is a registered trademark of RB Pharmaceuticals Limited

Subutex is a registered trademark of RB Pharmaceuticals Limited

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup