おすすめの製品
グレード
certified reference material
品質水準
フォーム
liquid
特徴
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
メーカー／製品名
Cerilliant®
濃度
1.0 mg/mL in methanol
テクニック
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
アプリケーション
forensics and toxicology
フォーマット
single component solution
保管温度
−20°C
SMILES記法
O=NN1CCCC1c2cccnc2
InChI
1S/C9H11N3O/c13-11-12-6-2-4-9(12)8-3-1-5-10-7-8/h1,3,5,7,9H,2,4,6H2
InChI Key
XKABJYQDMJTNGQ-UHFFFAOYSA-N
関連するカテゴリー
詳細
N′-Nitrosonornicotine, also known as NNN, is a nitrosamine and potential carcinogen found in a variety of tobacco products including snuff, cigarettes, chewing tobacco, and cigars. This Certified Spiking Solution® is suitable for use in nicotine testing or environmental monitoring by LC-MS/MS or GC/MS.
アプリケーション
- Validated Stability Indicating Chromatographic Methods for Quantification of Imidocarb Dipropionate; Application for the Determination of Its Residues in Bovine Meat and Milk Samples.: This study developed and validated chromatographic methods using silica gel 60 F₂₅₄ TLC plates to quantify imidocarb dipropionate residues in bovine meat and milk, highlighting the technique′s stability and reliability in complex matrices (Sedik et al., 2020).
- Development and Validation of Chromatographic Methods for Simultaneous Determination of Paracetamol, Orphenadrine Citrate and Caffeine in Presence of P-aminophenol; Quantification of P-aminophenol Nephrotoxic Impurity Using LC-MS/MS.: This research outlines the development and validation of chromatographic methods on silica gel 60 F₂₅₄ TLC plates for analyzing paracetamol, orphenadrine citrate, and caffeine alongside their nephrotoxic impurities, demonstrating the plate′s effectiveness in simultaneous multi-analyte detection (Boltia et al., 2020).
- Simultaneous Quantification of Chlorpheniramine, Phenylephrine, Guaifenesin in Presence of Preservatives with Detection of Related Substance Guaiacol in their Cough Syrup by RP-HPLC and TLC-Densitometric Methods.: This study developed RP-HPLC and TLC-densitometric methods using silica gel 60 F₂₅₄ TLC plates for the quantification of active ingredients and preservatives in cough syrup, showcasing the plate′s utility in pharmaceutical quality control (Boltia et al., 2019).
- Quantitative Determination of Synthesized Genotoxic Impurities in Nifuroxazide Capsules by Validated Chromatographic Methods.: This work validated chromatographic methods using silica gel 60 F₂₅₄ TLC plates for quantifying genotoxic impurities in nifuroxazide capsules, emphasizing the plate′s precision in detecting trace contaminants (Abdelwahab et al., 2018).
- High-performance Thin-layer Chromatography Method Development, Validation, and Simultaneous Quantification of Four Compounds Identified in Standardized Extracts of Orthosiphon stamineus.: This research presents a validated HPTLC method on silica gel 60 F₂₅₄ TLC plates for simultaneous quantification of compounds in herbal extracts, highlighting the plate′s role in natural product analysis (Hashim et al., 2016).
法的情報
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
関連製品
製品番号
詳細
価格
(±)-Cotinine-d3 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
(±)-ニコチン-d4 溶液, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
(±)-Nornicotine-d4, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
ターゲットの組織
Eyes
保管分類コード
3 - Flammable liquids
WGK
WGK 2
引火点(°F)
51.8 °F - closed cup
引火点(℃)
11.0 °C - closed cup
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
消防法
第4類:引火性液体
アルコール類
危険等級II
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
N-075-CHK:
N-075-1ML:4548173985411
N-075-CC:
最新バージョンのいずれかを選択してください：
この製品を見ている人はこちらもチェック
Jian-Min Yuan et al.
Carcinogenesis, 32(9), 1366-1371 (2011-07-08)
N'-Nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific nitrosamines. NNN and NNK can induce cancers of the esophagus and lung, respectively, in laboratory animals, but data on human esophageal cancer are lacking. The association between levels of NNN and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)
Michael Urban et al.
Journal of analytical toxicology, 33(5), 260-265 (2009-08-13)
The tobacco-specific nitrosamine N'-nitrosonornicotine (NNN) is carcinogenic to humans (IARC Group 1). Assessing the tobacco smoke-related exposure to NNN by suitable biomarkers is of interest for risk evaluation. Recently, NNN and NNN-N-glucuronide have been quantified in urine of smokers. However
N-Nitrosamines (15 listings): N-Nitrosonornicotine.
Report on carcinogens : carcinogen profiles, 12, 320-321 (2011-08-24)
Irina Stepanov et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 17(4), 945-948 (2008-04-10)
Specific biomarkers of tobacco carcinogen uptake are critical for investigations of the role of tobacco smoke exposure in human cancers. Two new biomarkers of human exposure to tobacco-specific carcinogens have been recently developed by our research group: urinary N'-nitrosonornicotine (NNN)
Karen H Watanabe et al.
Regulatory toxicology and pharmacology : RTP, 55(2), 123-133 (2009-06-23)
The manner in which humans smoke cigarettes is an important determinant of smoking risks. Of the few investigators that have predicted cancer risks from smoking on a chemical-specific basis, most used mainstream cigarette smoke (MCS) carcinogen emissions obtained via machine
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）