H-110

Hydroxyitraconazole

100 μg/mL in methanol, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₃₅H₃₈Cl₂N₈O₅
• CAS番号: 112559-91-8
• 分子量: 721.63
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• フォーム: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 100 μg/mL in methanol
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: clinical testing
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: Clc1c(ccc(c1)Cl)C3(OC(CO3)COc4ccc(cc4)N5CCN(CC5)c6ccc(cc6)N7C=NN(C7=O)C(C(O)C)C)C[n]2ncnc2
• InChI: 1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3
• InChI Key: ISJVOEOJQLKSJU-UHFFFAOYSA-N

詳細

詳細

Hydroxyitraconazole is an active metabolite of itraconazole, an antifungal drug used for the treatment of fungal infections. Therapeutic drug monitoring of hydroxyitraconazole is utilized in the management of patients receiving itraconazole to ensure therapeutic levels of the drug have been achieved. This Certified Spiking Solution^® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of hydroxyitraconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

アプリケーション

• Hydroxyitraconazole Antifungal Research: Utilized prominently in antifungal research, Hydroxyitraconazole serves as a potent inhibitor in studies targeting resistant fungal strains, contributing significantly to the development of more effective antifungal therapies (Krug et al., 2023).


• Itraconazole Metabolite Study: As a major metabolite of itraconazole, Hydroxyitraconazole is crucial in pharmacokinetic studies to understand the metabolism of itraconazole, aiding in optimizing dosing for better therapeutic outcomes (Miljković et al., 2022).


• Pharmaceutical Research Chemicals: This compound is pivotal in pharmaceutical research, providing insights into the drug′s behavior in biological systems and its interaction with other pharmacological agents, thereby facilitating drug development and safety evaluations (Iwasaki et al., 2019).


• Antifungal Drug Discovery: Integral to antifungal drug discovery, Hydroxyitraconazole aids in screening and developing new drug candidates, especially those targeting difficult-to-treat infections, thus expanding the arsenal against global fungal threats (Müller et al., 2017).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup