860508P

C8 Ceramide (d18:1/8:0)

Avanti Research^™ - A Croda Brand 860508P, powder

• 別名: N-octanoyl-D-erythro-sphingosine
• 実験式（ヒル表記法）: C₂₆H₅₁NO₃
• CAS番号: 74713-59-0
• 分子量: 425.69
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• 形状: powder
• 包装: pkg of 1 × 5 mg (860508P-5mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 860508P
• 脂質タイプ: sphingolipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
• InChI Key: APDLCSPGWPLYEQ-WRBRXSDHSA-N

詳細

詳細

C8 Ceramide is a short chain ceramide and is cell permeable.

アプリケーション

C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.

生物化学的／生理学的作用

C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.

包装

5 mL Amber Glass Screw Cap Vial (860508P-5mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids