857393P

THI

2-acetyl-5-tetrahydroxybutyl imidazole, powder

• 別名: 2-acetyl-4-tetrahydroxybutyl imidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole; 2-ATHBI
• 実験式（ヒル表記法）: C₉H₁₄N₂O₅
• CAS番号: 94944-70-4
• 分子量: 230.22
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >98% (TLC)
• 形状: powder
• 包装: pkg of 1 × 1 mg (857393P-1mg)
• メーカー／製品名: Avanti Polar Lipids 857393P
• 脂質タイプ: sphingolipids; bioactive lipids
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• InChI Key: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

詳細

詳細

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

生物化学的／生理学的作用

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.

包装

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable