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Craig Zetterberg et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(8), 1286-1295 (2016-06-15)
(R)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide (VX-509, decernotinib) is an oral Janus kinase 3 inhibitor that has been studied in patients with rheumatoid arthritis. Patients with rheumatoid arthritis often receive multiple medications, such as statins and steroids, to manage the signs and symptoms of comorbidities
Shotaro Uehara et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 883-886 (2017-05-11)
Common marmosets (
Raghava Choudary Palacharla et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(2), 169-176 (2018-02-01)
The objective is to evaluate methoxsalen as an in vitro phenotyping tool in comparison to ABT as a nonspecific inactivator of P450 mediated metabolism. The reversible inhibition of methoxsalen and ABT against the P450, FMO, AO, MAO-A and -B, enzymes
Takayuki Amano et al.
Biochemical pharmacology, 151, 69-78 (2018-03-10)
Dantrolene is used for malignant hyperthermia during anesthesia, and it sometimes causes severe liver injury as a side effect. Dantrolene is metabolized to acetylaminodantrolene, which is formed via the reduction of dantrolene to aminodantrolene and subsequent acetylation. Formation of hydroxylamine
Kazuko Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1326-1333 (2014-06-11)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and
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