おすすめの製品
品質水準
アッセイ
≥98% (HPLC)
色
white to off-white
溶解性
DMSO: >10 mg/mL
ethanol: 240 mg/mL
SMILES記法
O=C1N(c2ccccc2)c3ccccc3C1(Cc4ccncc4)Cc5ccncc5
InChI
1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2
InChI Key
YEJCDKJIEMIWRQ-UHFFFAOYSA-N
遺伝子情報
rat ... Kcnj1(24521)
詳細
Linopiridine is a class of drugs that activates the nervous system and enhances the acetylcholine (Ach) in the brain. It can be prepared by reacting oxiindole with 4-picolyl chloride hydrochloride in the presence of a KF-Al2O3 catalyst.
生物化学的／生理学的作用
Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.
法的情報
Sold under exclusive license from DuPont.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
L134-VAR:
L134-10MG:
L134-50MG:
L134-BULK:
Chin-Wei Huang et al.
The international journal of neuropsychopharmacology, 11(5), 597-610 (2008-01-11)
Oxcarbazepine (OXC), one of the newer anti-epileptic drugs, has been demonstrating its efficacy on wide-spectrum neuropsychiatric disorders. However, the ionic mechanism of OXC actions in neurons remains incompletely understood. With the aid of patch-clamp technology, we first investigated the effects
Olga Zavaritskaya et al.
Hypertension (Dallas, Tex. : 1979), 61(1), 151-159 (2012-11-28)
KCNQ channels have been identified in arterial smooth muscle. However, their role in vasoregulation and chronic vascular diseases remains elusive. We tested the hypothesis that KCNQ channels contribute to periadventitial vasoregulation in peripheral skeletal muscle arteries by perivascular adipose tissue
Motoharu Yoshida et al.
Journal of neurophysiology, 98(5), 2779-2794 (2007-08-31)
The M-current (current through Kv7 channels) is a low-threshold noninactivating potassium current that is suppressed by muscarinic agonists. Recent studies have shown its role in spike burst generation and intrinsic subthreshold theta resonance, both of which are important for memory
Alexander R Mackie et al.
The Journal of pharmacology and experimental therapeutics, 325(2), 475-483 (2008-02-15)
Pressor effects of the vasoconstrictor hormone arginine vasopressin (AVP), observed when systemic AVP concentrations are less than 100 pM, are important for the physiological maintenance of blood pressure, and they are also the basis for therapeutic use of vasopressin to
Richardson N Leão et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13353-13364 (2009-10-23)
While the synaptic mechanisms involved in the generation of in vitro network oscillations have been widely studied, little is known about the importance of voltage-gated currents during such activity. Here we study the role of the M-current (I(M)) in the
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