936588

(S,R,S)-AHPC-acetamido-O-PEG2-C1-acid

≥95%

• 別名: (4R)-N-[2-[2-[2-(Carboxymethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, (S)-13-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-ylcarbonyl]-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecanoic acid, (S)-13-[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidine-1-carbonyl]-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecanoic acid, L-Prolinamide, N-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• 実験式（ヒル表記法）: C₃₀H₄₂N₄O₉S
• CAS番号: 2172820-10-7
• 分子量: 634.74
• MDL番号: MFCD33020891
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• ligand: VH032
• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder or crystals
• 色: white to beige
• 保管温度: 2-8°C
• SMILES記法: C([C@@H](NC(COCCOCCOCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• InChI: 1S/C30H42N4O9S/c1-19-26(44-18-32-19)21-7-5-20(6-8-21)14-31-28(39)23-13-22(35)15-34(23)29(40)27(30(2,3)4)33-24(36)16-42-11-9-41-10-12-43-17-25(37)38/h5-8,18,22-23,27,35H,9-17H2,1-4H3,(H,31,39)(H,33,36)(H,37,38)/t22-,23+,27-/m1/s1
• InChI Key: IVARPPZGMUAWCE-QSEAXJEQSA-N

詳細

アプリケーション

(S,R,S)-AHPC-acetamido-O-PEG2-C1-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:

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その他情報

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable