936197

AdQPhos Pd G3

• 別名: AdQPhos G3 Palladacycle, AdQPhos Palladacycle
• 実験式（ヒル表記法）: C₇₃H₇₂FeNO₃PPdS
• 分子量: 1236.66
• UNSPSCコード: 12352142
• NACRES: NA.22

特性

• アッセイ: ≥90%
• 品質水準: 100
• 形状: powder
• 反応適合性: reaction type: Cross Couplings
• 官能基: (palladium); phosphine
• SMILES記法: CS(O[Pd]1([P](C23C[C@H]4C[C@H](C[C@H](C4)C3)C2)(C56C[C@H]7C[C@H](C[C@H](C7)C6)C5)c8cccc8)[NH2]C(C=CC=C9)=C9C%10=C1C=CC=C%10)(=O)=O.c%11(C%12=CC=CC=C%12)c(C%13=CC=CC=C%13)c(C%14=CC=CC=C%14)c(C%15=CC=CC=C%15)c%11C%16=CC=CC=C%16.[Fe]

詳細

詳細

The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.

Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.

アプリケーション

In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable