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詳細
NanoFabTx™- PEG Lipid Mix; for synthesis of PEGylated liposomes is a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing PEGylated liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins and peptides. PEGylated liposomes are capable of encapsulating both hydrophilic and lipophilic compounds and are an effective mechanism to increase the efficiency of drug delivery by prolonging the lifetime of the drug-encapsulated liposome.
アプリケーション
NanoFabTx™ is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx™ provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
特徴および利点
- A ready-to-use nanoformulation lipid blend for the synthesis of PEGylated liposomes
- Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- Optimized lipid blend for stealth PEGylated liposomes for small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
法的情報
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
関連製品
製品番号
詳細
価格
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
922420-50MG:
922420-BULK:
922420-100MG:
922420-50MG-PW:
922420-100MG-PW:
922420-VAR:
最新バージョンのいずれかを選択してください:
Which polymers can make nanoparticulate drug carriers long-circulating?
Advanced Drug Delivery Reviews, 16, 141?155-141?155 (1995)
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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