907308

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol

≥95%

• 別名: Hydroxyl diazirine difluoro TIPS-alkyne, MI-PAL, Minimally interfering photoaffinity label, Photo-click tag, Probe building block
• 実験式（ヒル表記法）: C₁₄H₂₄F₂N₂OSi
• CAS番号: 2227014-08-4
• 分子量: 302.44
• UNSPSCコード: 12352200

特性

• アッセイ: ≥95%
• フォーム: liquid
• 利用可能性: available only in USA
• 保管温度: −20°C

詳細

アプリケーション

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol is a minimally interfering photo-affinity label (MI-PAL). Photoaffinity labeling is of growing interest in chemical biology and drug discovery research to characterize the non-covalent interactome and is used in protein profiling; the study of protein-protein interactions and complexes; and target engagement, identification, or validation studies. This MI-PAL contains a diazirine for UV light-induced (∼365 nm) covalent modification of a biological target with potential for downstream applications via the click chemistry-enabling alkyne tag. Its small size exhibits minimal perturbation of the interactions between proteins and the ligand or probe. The Woo lab demonstrated the electronic tuning of this MI-PAL with the placement of stability-imparting fluorine groups adjacent to the diazirine and alkyne. The alkyl fluorine ion losses are also a useful marker in collision-induced dissociation (CID) mass spectrometry experiments. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

その他情報

Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small moleculeeprotein interactions

安全性情報

• ピクトグラム: GHS02
• シグナルワード: Danger
• 危険有害性情報: H242
• 注意書き: P210 - P234 - P235 - P240 - P370 + P378 - P403
• 危険有害性の分類: Self-react. C
• 保管分類コード: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable