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Merck
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安全性情報

765686

Sigma-Aldrich

金ナノ粒子

50 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O

別名:

金コロイド

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About This Item

UNSPSCコード:
12162002
NACRES:
NA.23

物質

PEG 5000

品質水準

100

フォーム

dispersion in H2O
nanoparticles

包装

poly bottle of 1 mL

OD

50

直径

50 nm

pH

6.0-8.0 (25 °C)

溶解性

water: miscible

密度

1.00 g/cm3

λmax

535 nm

官能基

methoxy

保管温度

2-8°C

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詳細

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating is possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

アプリケーション

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
  • Studies show that 30-nm PEG-coated AuNPs have been successfully used to deliver tumor necrosis factor to solid tumors.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

特徴および利点

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

保管分類コード

12 - Non Combustible Liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

765686-1ML:
765686-BULK:
765686-VAR:
765686-1ML-PW:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
MKCQ8225
MKCL4539
MKBZ7330V
MKBN9370V
MKBL7657V

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特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

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文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
Cheng-Kuan Su et al.
Journal of chromatography. A, 1402, 1-7 (2015-05-26)
The extravasation of administered nano-drug carriers is a critical process for determining their distributions in target and non-target organs, as well as their pharmaceutical efficacies and side effects. To evaluate the extravasation behavior of gold nanoparticles (AuNPs), currently the most

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Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

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Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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