711489

1-ヒドロキシベンゾトリアゾール 水和物

wetted with not less than 20 wt. % water, 97% dry basis

• 別名: HOBt水和物
• 実験式（ヒル表記法）: C₆H₅N₃O · xH₂O
• CAS番号: 123333-53-9
• 分子量: 135.12 (anhydrous basis)
• Beilstein: 4515
• EC Number: 219-989-7
• UNSPSCコード: 12352000
• PubChem Substance ID: 329763060
• NACRES: NA.22

特性

• アッセイ: 97% dry basis
• 形状: powder
• 品質: wetted with not less than 20 wt. % water
• 組成: Water content, ~20%
• 反応適合性: reaction type: Addition Reactions
• mp: 155-158 °C (lit.)
• 溶解性: DMF: 0.1 g/mL, clear
• SMILES記法: [H]O[H].On1nnc2ccccc12
• InChI: 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
• InChI Key: PJUPKRYGDFTMTM-UHFFFAOYSA-N

詳細

詳細

1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.

アプリケーション

1-Hydroxybenzotriazole hydrate is used as an additive:

• In the oligonucleotide couplings.
• In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).

1-Hydroxybenzotriazole hydrate can also be used:

• In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.

安全性情報

• ピクトグラム: GHS02,GHS07
• シグナルワード: Danger
• 危険有害性情報: H207,H319,H412
• 注意書き: P210 - P212 - P230 - P233 - P280 - P370 + P380 + P375 - P501
• 危険有害性の分類: Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
• 保管分類コード: 4.1A - Other explosive hazardous materials
• WGK: WGK 1
• 引火点(°F): 314.6 °F
• 引火点(℃): 157 °C
• 個人用保護具 (PPE): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges