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About This Item
実験式（ヒル表記法）:
C11H12N2O2
CAS番号:
分子量:
204.23
MDL番号:
UNSPSCコード:
12352100
PubChem Substance ID:
NACRES:
NA.22
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アッセイ
99%
mp
184-186 °C (lit.)
官能基
ketone
SMILES記法
CN1N(c2ccccc2)C(=O)C(O)=C1C
InChI
1S/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3
InChI Key
SKVPTPMWXJSBTF-UHFFFAOYSA-N
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詳細
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine. It is a metabolite of antipyrine.
アプリケーション
4-Hydroxyantipyrine was used to study the relationships between the metabolism of antipyrine, hexobarbitone and theophylline in man. It was used in a study on flow injection analysis system for the characterisation of pharmaceutical compounds via combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight mass spectrometry.
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
109428-VAR:
109428-BULK:
109428-5G:
M Monshouwer et al.
Xenobiotica; the fate of foreign compounds in biological systems, 25(5), 491-499 (1995-05-01)
1. In order to investigate the effect of a bacterial acute phase response model on drug disposition in vivo, plasma clearances of antipyrine, caffeine, paracetamol and indocyanine green were investigated in the healthy and Actinobacillus pleuropneumoniae-infected pig. 2. Indocyanine green
G Engel et al.
Clinical pharmacology and therapeutics, 59(6), 613-623 (1996-06-01)
Antipyrine has been widely used as a probe drug for human oxidative drug metabolism. To evaluate the role of antipyrine as a model drug, we have identified the cytochrome P450 enzymes involved in 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. We used
Reaction of drugs with nitrous acid as a source of carcinogenic nitrosamines.
W Lijinsky
Cancer research, 34(1), 255-258 (1974-01-01)
S B Seredenin et al.
Biulleten' eksperimental'noi biologii i meditsiny, 110(11), 491-493 (1990-11-01)
Antipyrine oxidation was studied in C57BL/6 and BALB/c inbred mice. It was found that C57BL/6 are weak oxidant but BALB/c are strong oxidants of antipyrine. Animals F1 hybrids inherited the high capacity of antipyrine oxidation.
R P Shrewsbury et al.
Research communications in chemical pathology and pharmacology, 64(3), 455-462 (1989-06-01)
Antipyrine metabolism was determined after hemodilution with 40 ml/kg of Fluosol in conscious, unrestrained female and male rats. Rats received an intravenous antipyrine dose (20 mg/kg) 24, 48, or 72 hours after hemodilution and the pharmacokinetic parameters were compared to
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