Y0002055

Fingolimod hydrochloride

European Pharmacopoeia (EP) Reference Standard

• Sinonimo/i: FTY720, 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride
• Formula empirica (notazione di Hill): C₁₉H₃₃NO₂ · HCl
• Numero CAS: 162359-56-0
• Peso molecolare: 343.93
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Origine biologica: synthetic
• Grado: pharmaceutical primary standard
• agenzia: EP
• Famiglia di API: fingolimod
• Forma fisica: powder
• Confezionamento: pkg of 110 mg
• Produttore/marchio commerciale: EDQM
• Condizioni di stoccaggio: protect from light
• Solubilità: water: 100-1000 g/L
• applicazioni: pharmaceutical
• Formato: neat
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H; SWZTYAVBMYWFGS-UHFFFAOYSA-N

Descrizione

Descrizione generale

Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Azioni biochim/fisiol

FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H373
• Consigli di prudenza: P260 - P314 - P501
• Classi di pericolo: STOT RE 2
• Organi bersaglio: Immune system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable