Z0167

Zearalanone

• Sinonimo/i: 2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone
• Formula empirica (notazione di Hill): C₁₈H₂₄O₅
• Numero CAS: 5975-78-0
• Peso molecolare: 320.38
• Numero MDL: MFCD00135821
• Codice UNSPSC: 12352200
• ID PubChem: 24902160
• NACRES: NA.77

Proprietà

• Sterilità: non-sterile
• Livello qualitativo: 200
• Saggio: ≥98% (TLC)
• Forma fisica: powder
• Solubilità: methanol: 9.80-10.20 mg/mL, clear, colorless
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1
• InChI: 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,20-21H,2-9H2,1H3/t12-/m0/s1; APJDQUGPCJRQRJ-LBPRGKRZSA-N
• Informazioni sul gene: rat ... Ar(24208)

Descrizione

Descrizione generale

Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.

Applicazioni

Zearalanone has been used:

• as mycotoxin to study its effects on the histology of ovaries in pre-pubertal bitches
• as a mycotoxin to investigate its influence on selected immunological, haematological and biochemical indexes in bitches
• as a standard to develop calibration curves in order to study its effects on progesterone and 17β-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs
• as a standard to develop calibration curves to study its level of intoxication in women with neoplastic lesions in the reproductive tract

Azioni biochim/fisiol

Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332,H315,H319,H335,H351
• Consigli di prudenza: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges