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Merck
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Documenti fondamentali

T6830

Sigma-Aldrich

Thyroglobulin human

Sinonimo/i:

Thyroglobulin human

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About This Item

Numero CAS:
9010-34-8
Numero CE:
232-721-3
Numero MDL:
MFCD01324794
Codice UNSPSC:
12352202
NACRES:
NA.56

Origine biologica

human

Livello qualitativo

200

Saggio

≥95% (SDS-PAGE)

Stato

lyophilized solid

tecniche

cell culture | mammalian: suitable

N° accesso UniProt

P01266

Temperatura di conservazione

2-8°C

Informazioni sul gene

human ... TG(7038)

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Descrizione generale

Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Graves′ disease, frequently develop antibodies against human Thyroglobulin. Thryoglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and in Graves′ disease.

Azioni biochim/fisiol

Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
SLCF8398
SLCC7415
SLCB3312
SLCB3313
SLCB3315

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Ricardo Adaixo et al.
Nature communications, 13(1), 61-61 (2022-01-12)
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine
E Resetkova et al.
Regional immunology, 4(4), 204-208 (1992-07-01)
Platelet activating factor (PAF), a phospholipid mediator, has been found to play a role in immune reactions, as well as in many pathophysiological alterations in certain disorders. To determine whether there might be a potential role of PAF in the
C Nascimento et al.
European journal of endocrinology, 169(5), 689-693 (2013-08-14)
Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/l-T4) are not well defined.
Rodrigo Moreno-Reyes et al.
The Journal of clinical endocrinology and metabolism, 98(9), 3694-3701 (2013-07-13)
Many countries in Europe remain mildly iodine deficient but relatively few country-level data exist on mild iodine deficiency (MID) and its impact on thyroid function in pregnant women. To determine the prevalence of thyroid disorders in pregnant women in Belgium
Sif Gudbrandsdottir et al.
Journal of immunology (Baltimore, Md. : 1950), 191(8), 4059-4067 (2013-09-21)
Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG)
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