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T9145

Sigma-Aldrich

Thyroglobulin from bovine thyroid

(For Gel Filtration Chromatography)

Sinonimo/i:

Tg

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About This Item

Numero CAS:
9010-34-8
Numero CE:
232-721-3
Numero MDL:
MFCD00132429
Codice UNSPSC:
12352202
NACRES:
NA.56

Origine biologica

bovine thyroid

Livello qualitativo

200

Forma fisica

powder

PM

~670 kDa

tecniche

bioconjugation: suitable

N° accesso UniProt

P01267

Temperatura di conservazione

−20°C

Informazioni sul gene

cow ... TG(280706)

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Applicazioni

Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Azioni biochim/fisiol

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Andrew N Hoofnagle et al.
Clinical chemistry, 54(11), 1796-1804 (2008-09-20)
Quantification of serum tumor markers plays an important role in determining whether patients treated for cancer require further therapy. Whereas large-scale proteomic efforts aim to identify novel tumor markers to facilitate early detection, optimization of methods for quantifying known tumor
Morgan E Abernathy et al.
NPJ vaccines, 6(1), 126-126 (2021-10-27)
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from
Perrine Munier et al.
Annales de biologie clinique, 69(6), 721-725 (2011-11-30)
Thyroglobuline (Tg) is a large molecule of high molecular weight mainly indicated in monitoring differentiated thyroid cancer (DTC), its measurement remains difficult. We report the case of a patient who underwent total thyroidectomy for a poorly differentiated thyroid insular carcinoma.
Akio Yoshida et al.
The Journal of clinical endocrinology and metabolism, 94(2), 442-448 (2008-12-04)
Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism. It is unknown whether pendrin is recognized by autoantibodies. Our objective was to examine the prevalence
Kouame Adou et al.
Analytical chemistry, 81(24), 10186-10192 (2009-11-21)
A charge reduction (CR) interface for electrospray ionization that permits simultaneous analysis of nanoparticle solutions by multiple detection methods was characterized. In the direct infusion configuration, a constant flow of analyte solution undergoes electrospray ionization (ESI). The charged aerosol is
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