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T1001

Sigma-Aldrich

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

Sinonimo/i:

Globulins thyro, Thyractin

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About This Item

Numero CAS:
9010-34-8
Numero CE:
232-721-3
Numero MDL:
MFCD00132429
Codice UNSPSC:
12352202
NACRES:
NA.61

Origine biologica

bovine thyroid

Livello qualitativo

200

Saggio

≥90% (agarose gel electrophoresis)

Forma fisica

powder

PM

~670 kDa

Composizione

Iodine, ≥0.20%

Tenore di azoto

13.0-16.0% total

Ceneri

≤4%

Solubilità

H2O: 20 mg/mL

N° accesso UniProt

P01267

Temperatura di conservazione

−20°C

Informazioni sul gene

cow ... TG(280706)

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Applicazioni

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Azioni biochim/fisiol

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Molecular & cellular proteomics : MCP, 8(4), 846-856 (2008-12-17)
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