Passa al contenuto
Merck
Tutte le immagini(3)

Key Documents

View All Documentation

SML1236

Sigma-Aldrich

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC)

Sinonimo/i:

(−)-Nicotine ditartrate, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(3)

About This Item

Formula empirica (notazione di Hill):
C10H14N2 · 2C4H6O6
Numero CAS:
65-31-6
Peso molecolare:
462.41
Numero CE:
200-607-2
Codice UNSPSC:
12352210
ID PubChem:
329825736
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Attività ottica

[α]/D +20 to +26°, c = 1.0 in water

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 20 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1
RYYKFQGHMYGLEL-PPHPATTJSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).
(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.

Azioni biochim/fisiol

NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Avvertenze

Danger

Indicazioni di pericolo

H301,H319,H330,H361d,H411

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

289.8 °F

Punto d’infiammabilità (°C)

143.2 °C

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 3

1 of 3

(−)-Nicotine PESTANAL®, analytical standard

Supelco

36733

(−)-Nicotine

Nicotine for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001023

Nicotine for system suitability

vibrant-m

BP821

(−)-Nicotine hydrogen tartrate salt dihydrate

Metabolism and disposition kinetics of nicotine.
Hukkanen J, et al.
Pharmacological Reviews, 57(1), 79-115 (2005)
Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine
Ozra Dehkordi et al.
Journal of neuroscience research, 93(2), 230-243 (2014-09-17)
Direct actions of nicotine in the CNS appear to be essential for its reinforcing properties. However, activation of nicotinic acetylcholine receptors (nAChRs) on afferent sensory nerve fibers is an important component of addiction to, and withdrawal from, cigarette smoking. The
All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium.
Radu B M, et al.
Scientific Reports, 7(1), 5083-5083 (2017)
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
Wang H, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 113, 118-131 (2017)
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.