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Key Documents

S0929

Sigma-Aldrich

Scopolamine hydrobromide

meets USP testing specifications

Sinonimo/i:

(−)-Scopolamine hydrobromide trihydrate, Hyoscine hydrobromide, Scopine tropate

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About This Item

Formula empirica (notazione di Hill):
C17H21NO4 · HBr · 3H2O
Numero CAS:
Peso molecolare:
438.31
Beilstein:
6100669
Numero MDL:
Codice UNSPSC:
12352116
ID PubChem:
NACRES:
NA.21

agenzia

USP/NF
meets USP testing specifications

Livello qualitativo

Punto di fusione

195-199 °C (dry matter) (lit.)

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

O.O.O.Br.CN1[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.BrH.3H2O/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;;;;/h2-6,11-16,19H,7-9H2,1H3;1H;3*1H2/t11-,12-,13-,14+,15-,16+;;;;/m1..../s1
LACQPOBCQQPVIT-SEYKEWMNSA-N

Informazioni sul gene

human ... CHRM1(1128)

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Applicazioni

Scopolamine hydrobromide has been used as a muscarinic receptor antagonist:
  • to reverse the cardiac effects of physostigmine in rabbit heart
  • to study its effect on acoustic startle reflex (gap-PPI){148)
  • to study it′s in vitro antiviral, antibacterial, and antifungal activities and cytotoxicity
  • to study its effect on conditioning of lever pressing

Azioni biochim/fisiol

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Pittogrammi

Skull and crossbones

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices. This study examined the contribution of
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Acta Acad. Med. Sin., 1(1), 14-23 (2011)
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Winter J, et al.
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