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Documenti fondamentali

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S7882

Sigma-Aldrich

(−)-scopolamina N-butilbromuro

≥98% (TLC), powder

Sinonimo/i:

(−)-N-butilscopolamina bromuro, Joscina N-butil bromuro

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About This Item

Formula empirica (notazione di Hill):
C21H30BrNO4
Numero CAS:
149-64-4
Peso molecolare:
440.37
Numero CE:
205-744-1
Numero MDL:
MFCD00078561
Codice UNSPSC:
12352116
ID PubChem:
24277872
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (TLC)

Stato

powder

Attività ottica

[α]25/D −20.8°, c = 3 in H2O(lit.)

Colore

white

Solubilità

H2O: 50 mg/mL

Stringa SMILE

[Br-].[H][C@@]12C[C@H](C[C@@]([H])([C@]3([H])O[C@]13[H])[N+]2(C)CCCC)OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1
HOZOZZFCZRXYEK-GSWUYBTGSA-M

Informazioni sul gene

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Applicazioni

(−)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.8

Azioni biochim/fisiol

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.
Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.5 The central effects include hallucinations, disorientation, restlessness and euphoria.6 Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.7

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H332

Classi di pericolo

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCG9318
BCCD7058
BCCB8329
BCCB2016
BCBG1559V

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(−)-Scopolamine hydrochloride analytical standard

Supelco

37022

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Metamizole sodium hydrate ≥98% (HPLC)

Sigma-Aldrich

SML1488

Metamizole sodium hydrate

Tropic acid 98%

Sigma-Aldrich

T89206

Tropic acid

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Supelco

PHR1005

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1-Bromobutane ReagentPlus®, 99%

Sigma-Aldrich

B59497

1-Bromobutane

Jens Ohnesorge et al.
Electrophoresis, 26(12), 2360-2375 (2005-06-01)
Different approaches were chosen to examine ionization reproducibility of analytes after separation by capillary electrophoresis-mass spectrometry (CE-MS) in a commercially available sheath-flow electrospray interface. For this task three different standard samples were examined. Sample 1 contained neostigmine bromide (cationic), paracetamol
K Kurahashi et al.
Life sciences, 61(8), 831-838 (1997-01-01)
The inhibitory effects of atropine, cimetropium, pirenzepine and N-butylscopolamine on the vagal afferent gastric excitatory response in cats under anesthesia with pentobarbital sodium and infusion of gallamine were examined. Electrical stimulation of vagal trunk in left side (10 Hz in
S Lin et al.
Digestive diseases and sciences, 42(5), 907-914 (1997-05-01)
Expression of muscarinic receptor subtypes in rat gastric smooth muscle was examined with reverse transcriptase-polymerase chain reaction (RT-PCR). Under the condition for detecting the messages of m1-m4 subtypes in brain, atrium, and gastric mucosa, only the fragments of m2 and
Margriet C de Haan et al.
European journal of radiology, 81(8), e910-e916 (2012-06-12)
Compare colonic distension and perceived burden of CT-colonography between participants receiving hyoscine butylbromide (buscopan) and glucagon hydrochloride as bowel relaxant. Data were collected within a screening trial. Participants received 20mg buscopan intravenously or 1mg of glucagon intravenously (if buscopan contra-indicated).
J Künzel et al.
Reproductive biomedicine online, 23(1), 132-140 (2011-07-16)
To compare the effects of neurotropic and musculotropic spasmolytic drugs in isolated swine uterus specimens, 80 swine uteri were perfused using an established model for preserving a viable organ that responds to oxytocic hormones and spasmolytic drugs. An intrauterine catheter
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