N0267

(±)-Nicotine

≥99% (TLC), liquid

• Formula empirica (notazione di Hill): C₁₀H₁₄N₂
• Numero CAS: 22083-74-5
• Peso molecolare: 162.23
• Beilstein: 82108
• Numero MDL: MFCD00065370
• Codice UNSPSC: 12352210
• eCl@ss: 39151701
• ID PubChem: 24897418
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥99% (TLC)
• Stato: liquid
• Attività ottica: [α]25/D 0°(lit.)
• Colore: yellow
• Solubilità: ethanol: 50 mg/mL
• Densità: 1.02 g/mL at 25 °C (lit.)
• Stringa SMILE: CN1CCCC1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3; SNICXCGAKADSCV-UHFFFAOYSA-N
• Informazioni sul gene: human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) ; rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

Descrizione

Applicazioni

(±)-Nicotine has been used:

• as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
• as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
• as a test compound to study its effects on fibril formation

Azioni biochim/fisiol

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

Prototype nicotinic acetylcholine receptor agonist.

Confezionamento

The material is liquid, transparent, and viscous, packaged in amber vail, and the volume inserted into each bottle is very small, It may form a thin FILM on the sides. While it may be difficult to see the material inside by the eyes, the container is not empty.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330,H315,H318,H411
• Consigli di prudenza: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 213.8 °F - closed cup
• Punto d’infiammabilità (°C): 101 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter