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SML0837

Sigma-Aldrich

FAK Inhibitor 14

≥95% (HPLC)

Sinonimo/i:

1,2,4,5-Benzene tetraamine tetrahydrochloride, 1,2,4,5-Benzenetetraamine 4HCl, 1,2,4,5-Benzenetetraamine tetrahydrochloride, Benzene-1,2,4,5-tetramine tetrahydrochloride, NSC 667249, Y15

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About This Item

Formula empirica (notazione di Hill):
C6H10N4 · 4HCl
Numero CAS:
4506-66-5
Peso molecolare:
284.01
Numero CE:
224-822-6
Codice UNSPSC:
12352200
NACRES:
NA.77

Saggio

≥95% (HPLC)

Stato

powder

Condizioni di stoccaggio

desiccated

Colore

, faint purple to dark brown

Solubilità

H2O: 20 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

[Cl-].[Cl-].[Cl-].[Cl-].Nc1c(cc(c(c1)N)N)N.[H+].[H+].[H+].[H+]

InChI

1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
BZDGCIJWPWHAOF-UHFFFAOYSA-N

Applicazioni

FAK Inhibitor 14 has been used in the metastasis assay. It is also used to study its effect on bone morphogenetic protein 7 (BMP-7)-induced cell crawling and adhesion.

Azioni biochim/fisiol

1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor.
1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14; Y15) is a cell-permeable, selective focal adhesion kinase (FAK) inhibitor. Focal adhesion kinase (FAK) is essential in regulating integrin signaling pathways responsible for cell survival, cell proliferation and motility. Phosphorylation of FAK tyrosine 397 (Y397) forms a high affinity binding site for the SH2 domain of the Src family kinases and PI3 kinase. FAK is overexpressed in a number of human tumors. 1,2,4,5-Benzenetetraamine tetrahydrochloride (FAK Inhibitor 14, Y15) blocks phosphorylation of Y397-FAK, which results in neuroblastoma cell detachment and apoptosis.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Fak page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
085M4705V
103M4738V

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