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L9783

Sigma-Aldrich

Leupeptin hydrochloride

powder, ≥90% (HPLC)

Sinonimo/i:

Acetyl-Leu-Leu-Arg-al hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C20H38N6O4 · HCl
Numero CAS:
24125-16-4
Peso molecolare:
463.01
Numero MDL:
MFCD00133457
Codice UNSPSC:
12352202
ID PubChem:
24896529
NACRES:
NA.77

Nome del prodotto

Leupeptin hydrochloride, microbial, ≥90% (HPLC)

Origine biologica

microbial

Livello qualitativo

200

Saggio

≥90% (HPLC)

Stato

powder

Solubilità

water: 50 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
OQQYPQNFLLAILR-UHFFFAOYSA-N

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Azioni biochim/fisiol

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Risultati analitici

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
109M4105V
119M4008V
109M4030V
50190508
068M4005V

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