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Key Documents

SAB4500068

Sigma-Aldrich

Anti-p27 KIP1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CDKN1B, CDN1B, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, KIP1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 22 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P46527

N° accesso UniProt

P46527

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CDKN1B(1027)

Descrizione generale

Anti-p27 KIP1 Antibody detects endogenous levels of total p27 KIP1 protein.
Cyclin-dependent kinase inhibitor 1B (CDKN1B or p27 KIP1) is a member of CDK inhibitor (CKI). The CDKN1B gene is mapped to human chromosome 12p13.1. The prime domains in CDKN1B include the nuclear export signal (NES) and the nuclear localization signal (NLS) and the CDK binding domain.

Immunogeno

The antiserum was produced against synthesized peptide derived from human p27 Kip1.

Immunogen Range: 1-50

Applicazioni

Anti-p27 KIP1 antibody produced in rabbit has been used in western blotting (1:500).

Azioni biochim/fisiol

Cyclin-dependent kinase inhibitor 1B (CDKN1B) negatively regulates cell cycle events by binding to cyclin-dependent kinase. It is a tumor suppressor gene correlated with the pathophysiology of tumors. Germline mutations in CDKN1B are implicated in multiple endocrine neoplasia (MEN) syndrome and MEN-like syndrome (MENX). It is a potent biomarker in acute myeloid leukemia.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Martina Kluth et al.
Oncotarget, 6(29), 27966-27979 (2015-08-22)
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical consequences of this alteration have not been studied in detail. Dual labeling fluorescence in situ hybridization using probes for 12p13 (CDKN1B; p27) and centromere 12
Ying Ding et al.
Molecular medicine (Cambridge, Mass.) (2015-04-01)
The process of islet transplantation for treating type 1 diabetes has been limited by the high level of graft failure that may be overcome by locally delivering trophic factors to enhance engraftment. Regenerating islet-derived protein 3 alpha (Reg3α) is a
Eliana Lucchinetti et al.
Anesthesiology, 116(4), 841-856 (2012-02-22)
Mesenchymal stem cells (MSC) are self-renewing clonal progenitor cells of nonhematopoietic tissues that exhibit a marked tropism to wounds and tumors. The authors' studies aimed at exploring how local anesthetics would affect MSC biology. Proliferation, colony formation, in vitro wound

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