MAB5680
Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody
clone 8-18C5, Chemicon®, from mouse
Sinonimo/i:
MOG
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
8-18C5, monoclonal
Reattività contro le specie
rat, mouse
Produttore/marchio commerciale
Chemicon®
tecniche
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG1
N° accesso Genebanck
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
mouse ... Mog(17441)
Descrizione generale
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG′s possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.
Specificità
May cross react with human and bovine based on sequence similarity.
Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].
Immunogeno
Epitope: The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.
Rat cerebellar glycoproteins
Applicazioni
Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuronal & Glial Markers
Neuronal & Glial Markers
Qualità
Routinely evaluated by immunoblot.
Descrizione del bersaglio
28 kDa
Stato fisico
Format: Purified
Purified immunoglobulin
Purified in 0.1 M Tris-Glycine, 0.15 M NaCl, pH 7.4 and 0.05% Sodium Azide
Stoccaggio e stabilità
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Risultati analitici
Control
brain lysate
brain lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Cristina Fernandez-Carbonell et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 22(2), 174-184 (2015-06-05)
To investigate the clinical and magnetic resonance imaging (MRI) features of anti-myelin oligodendrocyte glycoprotein (MOG) antibody-seropositive pediatric demyelinating syndromes. Serum samples collected from 74 children with suspected demyelinating disorders whom were being followed at Massachusetts General Hospital were incubated with
Adel Galeshi et al.
Neuropsychiatric disease and treatment, 15, 2681-2694 (2019-10-02)
Based on beneficial effects of aspirin and mesenchymal stem cells (MSCs) on myelin repair, in a preset study, effects of co-administration of aspirin and conditioned medium from adipose tissue-derived stem cells (ADSC-CM) on functional recovery of optic pathway, demyelination levels
Dan Xu et al.
The Journal of experimental medicine, 215(4), 1169-1186 (2018-03-01)
The pathophysiology of drug-resistant pediatric epilepsy is unknown. Flow cytometric analysis of inflammatory leukocytes in resected brain tissues from 29 pediatric patients with genetic (focal cortical dysplasia) or acquired (encephalomalacia) epilepsy demonstrated significant brain infiltration of blood-borne inflammatory myeloid cells
Denis Avey et al.
Cell reports, 24(13), 3619-3629 (2018-09-27)
Molecular and behavioral responses to opioids are thought to be primarily mediated by neurons, although there is accumulating evidence that other cell types play a prominent role in drug addiction. To investigate cell-type-specific opioid responses, we performed single-cell RNA sequencing
Rong He et al.
Molecular medicine reports, 16(1), 119-126 (2017-05-24)
Fasudil has been demonstrated to possess a protective effect in neural injury; however, its protective effect on convulsive brain injury remains to be assessed. The aim of the present study was to investigate the latent mechanism and effect of fasudil
Articoli
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
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