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PZ0162

Sigma-Aldrich

PD 0325901

≥98% (HPLC)

Sinonimo/i:

N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

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About This Item

Formula empirica (notazione di Hill):
C16H14F3IN2O4
Numero CAS:
391210-10-9
Peso molecolare:
482.19
Numero MDL:
MFCD08435926
Codice UNSPSC:
12352200
ID PubChem:
329823743

Saggio

≥98% (HPLC)

Forma fisica

powder

Attività ottica

[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol

Colore

white to off-white

Solubilità

DMSO: 20 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

FC1=C(NC2=CC=C(I)C=C2F)C(C(NOC[C@H](O)CO)=O)=CC=C1F

InChI

1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1
SUDAHWBOROXANE-SECBINFHSA-N

Informazioni sul gene

human ... MAP2K1(5604) , MAP2K2(5605)

Applicazioni

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).

Azioni biochim/fisiol

PD 0325901 by inhibiting mitogen-activated protein kinases (MAPKs) elicits growth-inhibitory and antiangiogenic effects on glioblastoma and melanoma tumor progression.
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Caratteristiche e vantaggi

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H373,H413

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 4 - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Millipore

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CHIR 98014 ≥98% (HPLC)

Sigma-Aldrich

SML1094

CHIR 98014

XAV939 ≥98% (HPLC)

Sigma-Aldrich

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ESGRO-2i Medium, 100ml to enhance viability of mouse embryonic stem and iPS cells

Sigma-Aldrich

SF016

ESGRO-2i Medium, 100ml

SB 431542 ≥98% (HPLC), powder

Sigma-Aldrich

S4317

SB 431542

Proteina LIF ricombinante di topo ESGRO® ESGRO Leukemia Inhibitory Factor (LIF) supplement for mouse ES cell culture. Each vial contains 10^7 units/ml.

Sigma-Aldrich

ESG1107

Proteina LIF ricombinante di topo ESGRO®

Proteina LIF ricombinante di topo ESGRO® ESGRO Leukemia Inhibitory Factor (LIF) supplement for mouse ES cell culture. Each vial contains 10^6 units/ml

Sigma-Aldrich

ESG1106

Proteina LIF ricombinante di topo ESGRO®

Ana Cuadrado et al.
Cell reports, 27(12), 3500-3510 (2019-06-20)
Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent transcription of pluripotency factors and repression of lineage-specification genes
Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway
Safaeinejad Z, et al.
European Journal of Cell Biology, 96(7), 665-672 (2017)
The role of autophagy in the treatment of BRAF mutant colorectal carcinomas differs based on microsatellite instability status
Koustas E, et al.
PLoS ONE, 13(11), e0207227-e0207227 (2018)
Kimita Suyama et al.
Cancer research, 78(1), 103-114 (2017-10-19)
The Akt pathway is a well-known promoter of tumor malignancy. Akt3 is expressed as two alternatively spliced variants, one of which lacks the key regulatory serine 472 phosphorylation site. Whereas the function of full-length Akt3 isoform (Akt3/+S472) is well-characterized, that
Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations
Ciuffreda L, et al.
Neoplasia, 11(8), 720-W6-720-W6 (2009)
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The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.

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