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PZ0181

Sigma-Aldrich

PD184352

≥98% (HPLC)

Sinonimo/i:

2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040

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About This Item

Formula empirica (notazione di Hill):
C17H14ClF2IN2O2
Numero CAS:
212631-79-3
Peso molecolare:
478.66
Numero MDL:
MFCD02683961
Codice UNSPSC:
51111800
ID PubChem:
329823755
NACRES:
NA.77

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to tan

Solubilità

DMSO: ≥30 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
GFMMXOIFOQCCGU-UHFFFAOYSA-N

Informazioni sul gene

human ... MAP2K1(5604) , MAP2K2(5605)

Azioni biochim/fisiol

PD184352 (CI-1040) is a highly selective MEK (MKK1; MAPK kinase) inhibitor.
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Caratteristiche e vantaggi

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H400

Consigli di prudenza

P273 - P391 - P501

Classi di pericolo

Aquatic Acute 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
051M4722V

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Supelco

Supelco

10257

Carbopack™ Adsorbent

Hiroshi Kiyonari et al.
Genesis (New York, N.Y. : 2000), 48(5), 317-327 (2010-02-18)
C57BL/6 mouse is the most standard strain in mouse genetics. The strain does, however, have several disadvantages; one being the difficulty in establishing embryonic stem (ES) cells. No reliable C57BL/6 ES cell line is widely available for creating mutant mice
Raymond R Mattingly et al.
The Journal of pharmacology and experimental therapeutics, 316(1), 456-465 (2005-10-22)
Type 1 neurofibromatosis (NF1) is a common autosomal dominant disorder that results in neuroectodermal tumors. The NF1 tumor-suppressor gene encodes neurofibromin, which includes a GTPase-activating domain for Ras inactivation. Affinity purification showed N-Ras to be the predominant activated isoform of
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Clinical cancer research : an official journal of the American Association for Cancer Research, 16(4), 1170-1178 (2010-02-11)
The extracellular signal-regulated kinase (ERK) pathway is upregulated in human cancers and represents a target for mechanism-based approaches to cancer treatment. However, specific blockade of the ERK pathway alone induces mostly cytostatic rather than proapoptotic effects, resulting in a limited
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Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we investigated the effect of Lebein on the p53-dependent growth of human colon adenocarcinoma cell
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