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Merck
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Documenti

P215

Sigma-Aldrich

PD 98,059

solid

Sinonimo/i:

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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About This Item

Formula empirica (notazione di Hill):
C16H13NO3
Numero CAS:
167869-21-8
Peso molecolare:
267.28
Numero MDL:
MFCD00671789
Codice UNSPSC:
12352200
ID PubChem:
24278666

Forma fisica

solid

Livello qualitativo

100

Colore

yellow

Solubilità

DMSO: 10 mg/mL, clear

Temperatura di conservazione

−20°C

Stringa SMILE

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
QFWCYNPOPKQOKV-UHFFFAOYSA-N

Informazioni sul gene

human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

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Applicazioni

PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
  • in culture medium for cell migration assay

Azioni biochim/fisiol

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Caratteristiche e vantaggi

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Note legali

Sold with permission of Warner Lambert Company.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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