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B5556

Sigma-Aldrich

Bay 11-7082

≥98% (HPLC), powder, NF-kB/TNF-α inhibitor

Sinonimo/i:

(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile

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About This Item

Formula empirica (notazione di Hill):
C10H9NO2S
Numero CAS:
19542-67-7
Peso molecolare:
207.25
Numero MDL:
MFCD00712162
Codice UNSPSC:
12352200
ID PubChem:
24891842
NACRES:
NA.77

Nome del prodotto

Bay 11-7082, ≥98% (HPLC), powder

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white

Solubilità

DMSO: >20 mg/mL
H2O: insoluble

Stringa SMILE

Cc1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI

1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
DOEWDSDBFRHVAP-KRXBUXKQSA-N

Applicazioni

Bay 11-7082 has been used as:
  • a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8
  • a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration
  • a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation

Azioni biochim/fisiol

Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway. In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes, human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells.
Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
065M4616V
063M4620V
121M4613V
090M46231V
090M4623

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Sigma-Aldrich

481406

NF-κB Activation Inhibitor

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Sigma-Aldrich

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SP600125 ≥98% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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Millipore

481408-M

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INF39 ≥98% (HPLC)

Sigma-Aldrich

SML2239

INF39

LY-294,002 hydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

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LY-294,002 hydrochloride

IKK Inhibitor III, BMS-345541 IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC₅₀ = ~ 300 nM).

Sigma-Aldrich

401480

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Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
Mori N, et al.
Blood, 100(5), 1828-1834 (2002)
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
Juliana C, et al.
The Journal of Biological Chemistry, 285(13), 9792-9802 (2010)
Guoping Cheng et al.
OncoTargets and therapy, 9, 7563-7571 (2016-12-23)
α-Catenin is an important molecule involved in the maintenance of cell-cell adhesion and a prognostic marker in cancer since its expression is essential for preventing cancer metastasis. However, the mechanism that leads to the downregulation of α-catenin in cancer progression
Mycoplasma hyorhinis induces epithelial-mesenchymal transition in gastric cancer cell MGC803 via TLR4-NF-kappaB signaling
Duan H, et al.
Cancer Letters, 354(2), 447-454 (2014)
The role of NF-kappa B signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264. 7 cells
Kim HR, et al.
Toxicology Letters, 233(2), 148-155 (2015)
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