481412

NF-kB Activation Inhibitor IV

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinonimo/i: NF-kB Activation Inhibitor IV, (E)-2-Fluoro-4ʹ-methoxystilbene
• Formula empirica (notazione di Hill): C₁₅H₁₃FO
• Numero CAS: 139141-12-1
• Peso molecolare: 228.26
• Numero MDL: MFCD12912333
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: crystalline solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Solubilità: DMSO: 20 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Fc1c(cccc1)\C=C\c2ccc(cc2)OC
• InChI: ILVFNAZMSMNXJG-RMKNXTFCSA-N

Descrizione

Descrizione generale

A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC₅₀ = 150 nM).

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
NF-κB Activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Heynekamp, J.J., et al. 2006. J. Med. Chem.49, 7182.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable