X3004

XAV939

≥98% (HPLC), powder, tankyrase inhibitor

• Sinonimo/i: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
• Formula empirica (notazione di Hill): C₁₄H₁₁F₃N₂OS
• Numero CAS: 284028-89-3
• Peso molecolare: 312.31
• Numero MDL: MFCD16879017
• Codice UNSPSC: 12352200
• ID PubChem: 329830802
• NACRES: NA.77

Proprietà

• Nome del prodotto: XAV939, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
• InChI: 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20); KLGQSVMIPOVQAX-UHFFFAOYSA-N

Descrizione

Applicazioni

XAV939 has been used in the inhibition

• of tankyrase in neuroblastoma cell lines
• of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
• of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Azioni biochim/fisiol

XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Altre note

XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable